武汉地区非淋菌性尿道炎患者泌尿生殖道支原体感染及药敏分析

目的：调查武汉地区非淋菌性尿道炎（NGU）患者泌尿生殖道支原体感染及耐药情况，为临床选择治疗支原体感染的抗生素提供参考依据。方法：采用支原体分离、鉴定、计数、药敏试剂盒检测拟诊为NGU患者的解脲脲原体（UU）和人型支原体（MH），并分析药敏试验结果。结果：630例患者中支原体总阳性率38．6％，以UU（30％）感染为主，男性感染率明显高于女性。药敏试验结果显示，UU、MH和UU＋MH对药物的敏感性最高者依次为阿奇霉素和美满霉素，uu对氧氟沙星、司帕沙星和罗红霉素耐药性高，MH及uu＋MH则对罗红霉素、红霉素和克拉霉素耐药性高。结论：uu成为本地区NGU的主要病原体，治疗本地区泌尿生殖道支原体感染可首选阿奇霉素和美满霉素。

Analysis of urogenital tract mycoplasma infection and drug sensitivity for NGU patients in Wuhan region

Objective： To investigate urogenital mycoplasma infection and drug resistance in patients with non- gonoeoccal urethritis （NGU） in Wuhan city in order to provide a reference for choosing antibiotics in treating my- coplasma infection. Method： Mycoplasma separation, identification, counting, susceptibility kit were used to de tect Ureaplasma urealyticum （UU） and Mycoplasma hominis （MH） in suspected patients with NGU, and ana- lyzed the results of susceptibility test. Result： The total mycoplasma positive rate was 38.6% in 630 patients, and mainly was UU infection （30%）. The infection rate in men was significantly higher than women. The results of susceptibility test showed that azithromycin and minocycline were the most sensitive to UU, MH respectively and UU ＋ MH together. Ofloxacin, sparfloxacin and roxithromycin emerged drug resistance in UU. Roxithromycin, erythromycin and clarithromycin were not sensitive to MH or UU ＋ MH. Conclusion： UU is the main pathogen of NGU in this region. Azithromycin and minocycline could be the priority for the treatment of urogenital myco-plasma infection.