2型糖尿病血清尿酸与颈动脉内膜中层厚度的关系

目的：探讨2型糖尿病（T2DM）患者血清尿酸（SUA）水平与颈动脉内膜中层厚度（IMT）的关系。方法：2011年8月～2012年6月内分泌科住院的157例T2DM患者，分为高血尿酸组（68例）及正常血尿酸组（89例）。记录患者身高、体重、腰围和臀围，测定空腹血糖（FBG）、血总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDLC）、空腹胰岛素（FINS）、IMT，并计算相应的体重指数（BMI）、腰臀比（WHR）、胰岛素抵抗指数（HOMA-IR）。结果：高血尿酸组BMI、WHR、FINS、HOMA—IR、LDL—C、TG、IMT较正常血尿酸组升高（P〈0．05），而FBG、TC、HDL—C两组差异无显著性（P〉0．05）。结论：2型糖尿病高血尿酸组更易出现血脂异常、胰岛素抵抗及动脉粥样硬化。

The relationship between serum level of uric acid and carotid artery intima-media thickness in type 2 diabetes mellitus

Objective：To investigate the relationship between serum level of uric acid （SUA） and carotid artery intima - media thickness （IMT） in type 2 diabetes mellitus（T2DM）. Methods：According to level of SUA, a total of 157 patients with T2DM visited in our department of endocrinology from August 2011 to Jun 2012 were divided into high SUA group （ n = 68 ） and normal SUA group （ n = 89） . Their body height,weight ,waist,hip were recorded ,the levels of fasting blood glucose （FBG） ,serum total cholesterol （TC） ,serum triglyceride（TG）,serum high density lipoprotein （HDL -C）,serum low density lipoprotein （LDL -C） ,fasting serum insulin （FINS）and IMT were determined, body mass index （BMI）, the waist to hip ratio（WHR） and insulin resistance index （ HOMA - IR） were calculated. Results： The levels of BMI, WHR, FINS, HOMA -IR, LDL - C, TG and IMT increased significantly in high SUA group compared with normal SUA group （ P 〈 0.05 ）, the levels of FBG, TC and HDL - C had no statistical significance between two groups （P 〉 0.05 ）. Conclusions： High SUA group in T2DM patients had remarkable dyslipidemia,insulin resistance and atherosclerosis.