|
|||||
|
|
| 尼莫地平缓释胶囊的研究 | |
| 引用本文： | 尼莫地平缓释胶囊的研究[J]. 中国药科大学学报, 1999, (5): 346-349. |
| 作者姓名： | 周建平 王立新 |
| 作者单位： | 中国药科大学药剂学教研室!南京，210009，山东新华制药厂!淄博，255005，山东新华制药厂!淄博，255005，中国药科大学药剂学教研室!南京，210009 |
| 摘 要： | 采用固体分散技术和微晶技术相结合的方法,研究和制备了尼莫地平缓释胶囊,采用吸附工艺和常规制粒机械,解决了工业化生产周期长、制粒难等问题。体内外试验结果表明：本品缓释效果明显,生物利用度高,体内外相关性好（r=0.992）。 |
| 关 键 词： | 尼莫地平 缓释胶囊 固体分散技术 微晶技术 生物利用度 |
Development of Nimodipine Sustained Release Capsules |
|
| Development of Nimodipine Sustained Release Capsules[J]. Journal of China Pharmaceutical University, 1999, (5): 346-349. | |
| Authors: | Zhou Jianping Wan Lixing Zhang Zhongming Zhang Junshou |
| Abstract: | A sustained release capsule of Nimodipine was developed using solid dispersion and microcrystalline techniques. The sustained release granules were prepared industrially with special absorbent and general machine without difficulty. The results of the capsules showed the prolonged effect, high bioavailabi1ity and good linear relationship between the cumulative releasing percent in witro and the absorptive percent in vivo(r=0. 992). |
| Keywords: | Nimodipine Sustained release capsules Solid dispersion Microcrystalline Bioavailability |
| 本文献已被 CNKI 维普 等数据库收录！ | |
| 点击此处可从《中国药科大学学报》浏览原始摘要信息 | |
| 点击此处可从《中国药科大学学报》下载全文 | |