|
|||||
|
|
| 拉米夫定治疗84例慢性乙型肝炎患者的临床疗效观察 | |
| 引用本文： | 刘新矿. 拉米夫定治疗84例慢性乙型肝炎患者的临床疗效观察[J]. 安徽卫生职业技术学院学报, 2008, 7(5): 26-27 |
| 作者姓名： | 刘新矿 |
| 作者单位： | 淮南市第一人民医院感染科,安徽,230022 |
| 摘 要： | 目的：研究拉米夫定对血清乙型肝炎病毒-脱氧核糖核酸（HBV-2DNA）阳性的慢性乙型肝炎病毒感染患者的疗效和安全性。方法：84例患者随机分成拉米夫定治疗组（43例）和对照组（41例）。治疗组每日口服拉米夫定100mg,疗程1年,对照组采用一般保肝、退黄、降酶治疗。结果：治疗组累计67.77%患者血清HBV-DNA阴转,最终持续阴转率67.44%。对照组HBV-DNA累计阴转率14.63%,最终阴转率为9.76%,两组疗效比较P〈0.01。治疗前丙氨酸转氨酶（ALT）增高的患者,52周时治疗组的复常率77.14%,对照组为18.18%,P〈0.01。52周时治疗组患者血清HBeAg最终持续阴转率40%,对照组HBeAg最终阴转率为7.14%,两组疗效比较P〈0.05。两组不良反应发生率比较,差别无显著性P〉0.05。结论：拉米夫定能明显降低血清HBV-DNA水平,促使ALT恢复正常,不良反应轻,耐受性好。 |
| 关 键 词： | 拉米夫定 慢性乙型肝炎 乙型肝炎病毒 |
Clinical Response Observation on Lamivudine to 84 Patients with Chronic Hepatitis B |
|
| LIU Xin-kuang. Clinical Response Observation on Lamivudine to 84 Patients with Chronic Hepatitis B[J]. Journal of Anhui Heaith Vocational & Technical College, 2008, 7(5): 26-27 | |
| Authors: | LIU Xin-kuang |
| Affiliation: | LIU Xin-kuang (Infectious Diseases Department, Huainan No.1 People＇s Hospital,Huainan 230022,Anhui) |
| Abstract: | Objective: to research Lamivudine's efficacy and safety on chronic Hepatitis B patients with HBV -2DNA positive. Methods:classifying the 84 patients into Lamivudine treatment group (43 patients) and control group (41 patients); treatment group taking 100mg Lamivudine orally per day for one year, and liver protecting, receding jaundice and reducing enzyme measures on control group. Results: 67.77% of treatment group patients' HBV-DNA turning to negative and final negative-conversion rate reaching 67.44% ; ac... |
| Keywords: | Lamivudine Chronic Hepatitis B Hepatitis B Virus |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |