Additional cytotoxic polyacetylenes from the marine sponge Petrosia species |
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| Authors: | Lim Y J Park H S Im K S Lee C Hong J Lee M Kim Dk D Jung J H |
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| Affiliation: | College of Pharmacy, Pusan National University, Pusan 609-735, Korea, Korea Research Institute of Chemical Technology, Taejon, Korea. |
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| Abstract: | ![]()
Ten new polyacetylenic alcohols (1-6, 8-11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1-11 were further evaluated for in vitro inhibitory activity on DNA replication. |
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