极快速减压对大鼠肺组织的损伤作用

目的]研究极快速减压对大鼠肺组织的损伤作用。方法]极快速减压处理后30min，对大鼠肺组织病理改变、肺湿干重比和支气管肺泡灌洗液（BALF）中总蛋白（TP）、肿瘤坏死因子α（TNFα）含量进行检测，并与常压空气组、缺氧组对比。结果]极快速减压处理后30min，大鼠肺组织具有损伤病理特征，肺湿干重比从（5．20±0．19）（常压空气组）、（5．19±0．22）（缺氧组）增至（5，60±0．31），P〈0．05；BALF中TP从（9．64±4．99）μg／mL（常压空气组）、（13．07±8．03）μg／mL（缺氧组）升高到（33．96±17．24）μg／mL，P〈0．01或P〈0．05；TNFα含量也从（29．17±0．57）pg／mL（常压空气组）、（29．35±0．62）pg／mL（缺氧组）升高到（30．22±0．31）pg／mL，P〈0．01或P〈0．05。结论]极快速减压能够导致大鼠发生急性肺损伤。

Rat Lung Injury Caused by Extremely Fast Decompression

Objective ] To study the rat lung tissue damage due to extremely fast decompression. Methods ] At 30 minutes after the extremely fast decompression, the lung wet/dry mass ratio, the pathological change and the content of TP, TNFα in the rat BALF were detected, and compared with normal air pressure group and anoxia group, Results] At 30 min after extremely fast decompression, the lung had the pathological character of damage, the lung wet/dry mass ratio increased to （5.60 ±0.31 ） as compared with（ 5.20±0.19 ）（ normal air group ）and（ 5.19±0.22 ）（ anoxia group ）, P 〈 0.05. The content of TP in the rat BALF increased to （ 33.96±17.24 ） pg/mL as compared with （ 9.64±4.99 ） lag/mL （ normal air group ） and （ 13.07±8.03 ）μg/mL （ anoxia group ）, P 〈 0.01 or P 〈 0.05. The content of TNFα in the rat BALF was also increased to（ 30.22 ± 0.31 ）pg/mL as compared with （ 29.17 ＋ 0.57 ） pg/mL （ normal air group ）, and （ 29.35 ± 0.62 ） pg/mL （ anoxia group ） P 〈 0.01 or P 〈 0.05. Conclusion ] Extremely fast decompression is capable of damaging the rat lung.