| 国产氨磷汀(WR-2721)对顺铂致肾毒性的保护作用 |
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| 引用本文： | 张康宣,蔡鸣,胡芝华.国产氨磷汀(WR-2721)对顺铂致肾毒性的保护作用[J].西北药学杂志,2001,16(4):159-161. |
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| 作者姓名： | 张康宣 蔡鸣 胡芝华 |
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| 作者单位： | 江苏省药物研究所药理室 |
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| 摘 要： | 腹腔注射国产放化疗保护剂氨磷汀能明显减低由顺铂 ( cis- Pt)引起的正常小鼠或大鼠的肾脏毒性 ,氨磷汀各剂量组血清尿素氮与 cis- Pt组相比显著降低 ( P <0 .0 1 ) ,同时可见肾脏组织学损害明显逆转 ,与进口对照品 amifostine( AFT)相比无显著差异。对接受放化疗的腹水型肝癌和肉瘤 - 1 80荷瘤小鼠以及体外培养人肺腺癌肿瘤细胞加用氨磷汀均不影响放化疗的疗效 ,国产品与进口品无明显差异
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| 关 键 词： | 氨磷汀 顺铂 肾毒性 放疗 化疗 |
| 修稿时间： | 2001年1月3日 |
Protective effects of domestic Anlingding(WR-2721) on nephrotoxicity induced by
cis-platin |
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| Abstract: | Anlinding, a domestic protectant for radiotherapeutics and chemotherapy, administered intraperitoneally may considerably reduced nephrotoxicity induced by cisplatin(cis-Pt) in normal mice and rats. Serum BUN in the groups under multiple doses of Anlingding was lower significantly than the one in cis Pt group(P<0 01). The marked inversion of renal histology damage was observed. No obvious differences were exhibited between Anlingding and control amifostine(AFT). The test also showed that Anlingding did not impair the effect of radiotherapeutics or chemotherapy on mice bearing either HepA or S 180 and human spc A 1 tumor cells incubated in vitro. |
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| Keywords: | Anlingding amifostine cisplatin nephrotoxicity radiotherapeutics chemotherapy |
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