BNIP3在人髓母细胞瘤中的表达及其与预后的关系

目的探讨BNIP3在人髓母细胞瘤中的表达及其与预后的关系。方法采用免疫组化S-P法检测30例髓母细胞瘤组织,10例正常小脑组织中BNIP3蛋白的表达,同时检测HIF-1α蛋白的表达。结果 30例髓母细胞瘤组织标本中有19例表达BNIP3,显著高于正常对照组（P〈0.01）;BNIP3主要表达于肿瘤细胞核;BNIP3表达与HIF-1α表达呈正相关（P〈0.05）。Kaplan-Meier生存分析提示BNIP3表达阳性组的累计生存情况较阴性组差,Cox回归分析表明BNIP3的高表达是一个独立危险因素。结论 BNIP3高表达在髓母细胞瘤的发生发展中可能具有重要作用,其表达可以作为判断肿瘤预后的指标。

Expression of BNIP3 and its prognostic value in human medulloblastoma

Objective To examine the expression of BNIP3 in medulloblastoma and the possible prognostic value.Methods Expressions of BNIP3 and its upstream proteins HIF-1α were ditected by immumohistochemical staining in 30 cases of medulloblastoma,10 cases of normal cerebellum tissue.Results Expression of BNIP3 was higher in medulloblastoma tissue than in normal cerebellum tissue(P<0.01);the expression of BNIP3 was mainly in nucleus;the expression of HIF-1α was positively related to that of BNIP3 in medulloblastoma tissue(P<0.05).In Kaplan-merier survival analysis,the five-year survival rate of the BNIP3 negative group was much higher than that of the positive group.In Cox regression analysis,BNIP3 was an independent risk factor for prognosis.Conclusion The high expression of BNIP3 plays an important role in carcinogenesis and development of medulloblastoma.Expression of BNIP3 is significantly associated with the prognosis of medulloblastoma.