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| 多发性脑膜瘤的临床和组织学研究 | |
| 引用本文： | 孔军,黄红光,詹仁雅,RALF Bu-hl.多发性脑膜瘤的临床和组织学研究[J].医学研究生学报,2006,19(5):451-453. |
| 作者姓名： | 孔军 黄红光 詹仁雅 RALF Bu-hl |
| 作者单位： | 1. 青岛市市立医院神经外科,山东,青岛,266011 2. 浙江大学医学院附属第一医院神经外科,浙江,杭州,310003 3. 德国基尔大学医学院神经外科,基尔,24098,德国 |
| 摘 要： | 目的：研究多发性脑膜瘤的临床和组织学特点.方法：对39例多发性脑膜瘤的临床资料进行回顾性分析,免疫组化检测孕激素受体（PR）、p53和细胞周期蛋白抗体MIB-1在多发性脑膜瘤中的表达,并与单发性脑膜瘤进行比较.结果：多发性脑膜瘤女性多见,肿瘤的分布较为广泛,大脑半球凸面为好发部位.免疫组化结果显示：PR的表达在多发性脑膜瘤比单发性脑膜瘤强,p53和MIB-1的表达则两者无显著性差异.结论：多发性脑膜瘤的诊断主要依靠影像学资料,其发生学可能与孕激素及其受体有关,单克隆起源的可能性较大. |
| 关 键 词： | 多发性脑膜瘤 诊断 组织学 孕激素受体 |
| 文章编号： | 1008-8199(2006)05-0451-03 |
| 修稿时间： | 2005年10月19 |
The clinical and histological study of multiple memingiomas |
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| KONG Jun,HUANG Hong-guang,ZHAN Ren-ya,RALF Bu-hl.The clinical and histological study of multiple memingiomas[J].Bulletin of Medical Postgraduate,2006,19(5):451-453. | |
| Authors: | KONG Jun HUANG Hong-guang ZHAN Ren-ya RALF Bu-hl |
| Abstract: | Objective:To study the clinical and histological features of multiple meningiomas. Methods:39 cases of multiple meningiomas were analyzed retrospectively. The expressions of PR (Progesterone receptor) , p53 and MIB-1 were detected by immunohistochemistry in the samples of multiple meningiomas and solitary meningiomas. Results:Female predominance was obvious in cases of multiple meningiomas. The tumors had wide distributions with a main location in brain convexity. The results of immunohistochemistry showed stronger expression of PR and similar expression of p53 and MIB-1 in samples of multiple meningiomas than those in solitary meningiomas. Conclusion:The diagnosis of multiple meningiomas mainly depends on radiological examination. The pathogenesis of multiple meningiomas is probably related to progesterone and its receptor, and it is most likely monoclonal origin. |
| Keywords: | Multiple meningiomas Diagnosis Histology Progesterone receptor |
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