The unusual transmembrane electron transporter DsbD and its homologues: a bacterial family of disulfide reductases |
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| Authors: | Porat Amir Cho Seung-Hyun Beckwith Jon |
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| Institution: | Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. |
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| Abstract: | The bacterial membrane protein DsbD transfers electrons across the cytoplasmic membrane to reduce protein disulfide bonds in extracytoplasmic proteins. Its substrates include protein disulfide isomerases and a protein involved in cytochrome c assembly. Two membrane-embedded cysteines in DsbD alternate between the disulfide-bonded (oxidized) and reduced states in this process. |
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