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| Wnt通路抑制因子Sfrp的研究进展 | |
| 引用本文： | 罗丽敏,王俐. Wnt通路抑制因子Sfrp的研究进展[J]. 医学综述, 2007, 13(10): 729-731 |
| 作者姓名： | 罗丽敏 王俐 |
| 作者单位： | 汕头大学医学院第一附属医院皮肤性病科,广东,汕头,515041 |
| 基金项目： | 广东省医学科学技术研究基金 |
| 摘 要： | 分泌型卷曲相关蛋白(Sfrp)通过具有同源结构的半胱氨酸富含区(CRD)与Wnt信号通路的特异性受体卷曲蛋白受体(Fz受体)竞争结合,从而抑制Wnt信号通路的传导。近年来,随着分子和基因水平的深入研究,发现Sfrp在抗肿瘤及调控细胞凋亡等方面发挥重要作用,从而为抗肿瘤研究以及调控组织和细胞的增殖与分化提供了新的思维模式。本文旨从Wnt与其通路抑制因子Sfrp的关系、Sfrp的组成与表达特点及Sfrp对机体的作用三个方面进行综述。 |
| 关 键 词： | 分泌型卷曲相关蛋白 Wnt蛋白 卷曲蛋白受体 |
| 文章编号： | 1006-2084（2007）10-0729-03 |
| 收稿时间： | 2006-09-10 |
| 修稿时间： | 2007-03-19 |
Research Progress of Sfrp, the Suppressor Factor of Wnt Signaling Pathway |
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| LUO Li-min,WANG Li. Research Progress of Sfrp, the Suppressor Factor of Wnt Signaling Pathway[J]. Medical Recapitulate, 2007, 13(10): 729-731 | |
| Authors: | LUO Li-min WANG Li |
| Affiliation: | Department of Dermatology, The First Affiliated Hospital, Medical College of Sbontou University, Sbontou 515041, China |
| Abstract: | Sfrp,a kind of secreted frizzled-related protein,can suppress the transduction of Wnt pathway signaling by competitive binding with Fz receptor.Fz receptor is a specific receptor of the Wnt signal signaling,which has the CRD structre,homologous with the CRD of Sfrp.Recently,with the further study in molecular and gene level,the important role of Sfrp on suppressing tumor growth and regulating apoptosis was revealed.which opens a new view for us on tumor study and regulation of the proliferation and differentiation of tissues and cells.This article reviews sfrp (suppressor factor of wnt pathway signaling) of its constitution and expression character,its relationship with Wnt pathway and its effect on body. |
| Keywords: | Sfrp Wnt Fz receptor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |