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| 一种组织工程骨修复兔股骨头坏死模型的效果评价 | |
| 引用本文： | 彭吾训,王蕾,邓进,李彦林,龚跃昆,李世和.一种组织工程骨修复兔股骨头坏死模型的效果评价[J].第三军医大学学报,2010,32(7). |
| 作者姓名： | 彭吾训 王蕾 邓进 李彦林 龚跃昆 李世和 |
| 作者单位： | 1. 贵阳医学院附属医院急诊创伤外科,贵阳,550004 2. 贵州省疾病预防控制中心职业病防治研究所,贵阳,550004 3. 昆明医学院第一附属医院骨科,昆明,650031 |
| 基金项目： | 贵州省科学技术基金项目(黔科合J字20072104)~~ |
| 摘 要： | 目的观察双相陶瓷生物骨(biphasic ceramic biologic bone,BCBB)、骨形态发生蛋白(bone morphogeneticprotein,BMP)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)、骨髓基质干细胞(mesenchymal stem cells,MSCs)复合培养形成的组织工程骨修复股骨头坏死(femoral head necrosis,FHN)模型病灶清除区缺损,评价该组织工程骨修复FHN的效果。方法取32只新西兰成年大白兔共64侧股骨头,微波灭活建立股骨头坏死模型,按随机数字表法分为4组,每组16侧。A组:空白对照组;B组:植入BCBB/BMP/bFGF;C组:植入BCBB/BMP/bFGF/MSCs;D组:植入自体松质骨。术后2、4、8、12周分批处死动物,每组每次处死4只。行股骨头大体及解剖观察、X线摄片、组织学观察、钙含量及钙磷比检测、血管免疫组织化学染色。结果股骨头大体及解剖观察:A组8周和12周各有一侧股骨头塌陷;B组2周时纤维结缔组织生长活跃;C、D组12周时植骨区与宿主骨界限不清。②X线评分:12周时,... |
| 关 键 词： | 股骨头坏死 双相陶瓷生物骨 碱性成纤维细胞生长因子 骨形态发生蛋白 骨髓基质干细胞 |
A tissue engineering bone to repair femoral head necrosis |
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| Peng Wuxun,Wang Lei,Deng Jin,Li Yanlin,Gong Yuekun,Li Shihe.A tissue engineering bone to repair femoral head necrosis[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(7). | |
| Authors: | Peng Wuxun Wang Lei Deng Jin Li Yanlin Gong Yuekun Li Shihe |
| Institution: | 1Department of Emergency and Trauma Surgery;Affiliated Hospital;Guiyang Medical College;Guiyang;Guizhou Province;550004;2Institute of Occupational Medicine;Guizhou Center for Disease Control and Prevention;3Department of Orthopaedics;First Affiliated Hospital;Kunming Medical College;Kunming;Yunnan Province;650032;China |
| Abstract: | Objective To explore the efficacy of a tissue engineering bone composed of biphasic ceramic biologic bone(BCBB),bone morphogenetic protein(BMP),basic fibroblast growth factor(bFGF)and mesenchymal stem cells(MSCs)in the repairing of necrotic areas of the femoral head.MethodsThe femoral head necrosis model of 64 femoral head in 32 rabbits was induced by microwave heating and then randomly divided into 4 groups,which were respectively implanted with nothing(group A),with BCBB/BMP/bFGF(group B),with BCBB/BMP/bF... |
| Keywords: | femoral head necrosis biphasic ceramic biologic bone basic fibroblast growth factor bone morphogenetic protein mesenchymal stem cells |
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