| mieroRNA-221和mieroRNA-222与恶性肿瘤的研究进展 |
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| 引用本文： | 张春智[综述],;康春生[审校],;浦佩玉[审校].mieroRNA-221和mieroRNA-222与恶性肿瘤的研究进展[J].国外医学(肿瘤学分册),2009(1):3-6. |
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| 作者姓名： | 张春智[综述] ;康春生[审校] ;浦佩玉[审校] |
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| 作者单位： | 天津医科大学总医院神经外科天津市神经病学研究所神经肿瘤室,300052 |
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| 基金项目： | 基金项目：国家自然科学基金资助项目（30772231）;教育部新世纪优秀人才支持计划资助项目（NCET-07-0615）;天津市科委国际合作项目（07ZCGHHZ01000） |
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| 摘 要： | 微RNA（microRNA）-221和microRNA-222是成簇的microRNA，在恶性肿瘤中起促癌作用，在胶质母细胞瘤、前列腺癌、乳头状甲状腺癌等恶性肿瘤中高表达。microRNA-221和microRNA-222通过调控其特定的靶基因行使促癌作用。在所有预测的靶基因中，p27^kip1和p57^kip2是已被验证的靶基因，microRNA-221和microRNA-222通过下调p27^kip1和p57kip2的表达来促进肿瘤的形成和生长。
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| 关 键 词： | 肿瘤 靶基因 临床研究 前列腺癌 |
Advance research on microRNA-221 ,microRNA-222 and malignant tumor |
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| Institution: | ZHANG Chun-zhi( Departrnent of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro- Oncology, Tianjin Neuro- logical Institute, Tianjin 300052, China) |
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| Abstract: | It has become dear that particular microRNAs（miRNAs） function either as tumor suppressors or oncogenes, whose loss or overexpression, respectively, has diagnostic and prognostic significance. MicroRNA-221 and microRNA-222 are a cluster microRNAs of oncogenes. They are overexpressed in some malig- nant tumors, including glioblstoma, prostate carcinoma, papillary thyroid carcinoma, and so on. By regulating particular target mRNAs, microRNA-221 and microRNA-222 perform prooncogenic role. p27kip1 and p57kip2 are target genes of microRNA-221 and microRNA-222. MicroRNA-221 and microRNA-222 promote oncogensis and tumor grow by down-regulating p27 kipl and p57kip2 expression. |
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| Keywords: | Neoplasms Target gene |
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