红花黄素对大鼠局灶性脑缺血再灌注损伤的保护作用

目的 研究红花黄素对大鼠局灶性脑缺血再灌注损伤(I/R)的保护作用。方法 采用线栓法制作大鼠大脑中动脉缺血再灌注模型。插入栓线前、插入栓线0.5h后以及再灌注2h后分别监测肛温、肢体II导联心电、股动脉压以及大脑局部脑血流量。大鼠清醒后，进行行为学评分，测定脑含水量并进行组织病理学检查。结果 红花黄素能显著提高缺血再灌注后局部脑血流量，对抗血压与心率变化，降低脑组织含水量，缩小脑梗死面积，减轻缺血所致组织病理改变。结论 红花黄素可以增加I/R脑血流量，恢复因缺血造成的自主神经功能损伤，对大鼠局灶性脑缺血再灌注损伤具有保护作用。

Effects of safflor yellow on focal cerebral ischemia-reperfusion injury in rats

Objective To investigate protective effects of safflor yellow against focal cerebral ischemia-reperfusion injury in rats.Methods Middle cerebral artery occlusion(MCAO) was used to prepare focal cerebral ischemia.Rectal temperature,ECG,femoral arterial pressure and regional cerebral blood flow(rCBF) in each rat were detected before MCAO,0.5h after occlusion and 2h after reperfusion.Then effects of safflor yellow were studied by determining neurological deficit,water content of brain tissues,cerebral infarcte...