丁二磺酸腺苷蛋氨酸联合异甘草酸镁对Ⅱ期原发性肝癌TACE治疗后保肝作用的对照研究

目的探讨丁二磺酸腺苷蛋氨酸(思美泰)联合异甘草酸镁(天晴甘美)对Ⅱ期原发性肝癌患者经肝动脉介入化疗栓塞(TACE)后急性肝功能损害的保护作用。方法 60例Ⅱ期原发性肝癌患者在TACE治疗术后进行保肝治疗,随机分为2组。治疗组(A组)30例在TACE后静脉滴注思美泰1000mg/d+天晴甘美200mg/d治疗;对照组(B组)30例在TACE后静脉滴注苦黄注射液50ml/d+天晴甘美200 mg/d治疗,每天1次,术后连用7 d。2组均在TACE治疗前、术后(第3、7天)抽血检查肝功能。结果 2组术后第3天ALT、AST、TBIL及DBIL均较术前有一定程度的升高(P<0.01),术后第7天肝功能均有一定程度的改善,优于术后第3天(P<0.01),且A组疗效优于B组,差异有统计学意义(P<0.01)。2组均未发生不良反应。结论思美泰联合天晴甘美对原发性肝癌TALE治疗后出现急性肝损害的近期保护效果满意,无明显不良反应,值得临床推广使用。

The clinical study on the liver-protection of S-adenosy-methionine combined with magnesium isoglycyrrhizinate in stage II hepatocellular carcinoma patients after TACE

Objective To study the effects of S-adenosy-methionine（SAMe） combined with magnesium isoglycyrrhi zinate for acute hepatic functional damage after trans-arterial chemoembolization（TACE）in the treatment of stageⅡhepatocellular carcinoma（HCC）.Methods Sixty cases of liver neoplasm after TACE were divided into two groups randomly.Group A（the treatment group,n =30）,SAMe 1000 mg/d plus magnesium isoglycyrrhizinate 200 mg/d were intravenously dripped after TACE.Group B（the control group,n =30）,Kuhuang injection 50 ml/d plus magnesium isoglycyrrhizinate 200 mg/d were intravenously dripped after TACE,lasted for 7days in both groups.The two groups were separately assessed the hepatic function on the day preoperatively and the 3th day,7th day postoperatively.Results All the hepatic functional labels changed markedly after TACE with ALT,AST,TBIL and DBIL rising to a certain extent on the 3th day postoperatively（P 0.01）.The labels decreased on the 7th day,there were significant statistical differences of ALT,AST,TBIL and DBIL between the 3th day postoperatively and 7th day postoperatively in two groups（P 0.01）.There were significant differences of the labels on the 7th day between the two groups（P 0.01）.No adverse reactions were observed in two groups.Conclusion The SAMe combined with magnesium isoglycyrrhizinate provided hepatic functional protection for stage II HCC patients after TACE,especially for the satisfactory short-term efficiency in acute liver damage.The method was safety and hence was worthy of clinical application.