| HLA与HPV相关肿瘤的研究进展 |
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| 引用本文： | 杨兰,孙振柱,李锋.HLA与HPV相关肿瘤的研究进展[J].国际病理科学与临床杂志,2006,26(4):12-324. |
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| 作者姓名： | 杨兰 孙振柱 李锋 |
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| 作者单位： | 新疆石河子医学院病理教研室,新疆,石河子,832002;新疆维吾尔自治区人民医院病理科,乌鲁木齐,830001 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)
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教育部高等学校科技创新工程项目 |
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| 摘 要： | 人乳头状瘤病毒（HPV）感染是宫颈癌等肿瘤的高危因素，其致瘤机制尚未完全阐明。在免疫应答过程中，机体HLA-I,Ⅱ,Ⅲ类分子表达异常与HPV相关肿瘤免疫逃避有关，可为宫颈癌、食管癌等肿瘤的病因学提供新的线索。
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| 关 键 词： | HLA HPV 宫颈癌 食管癌 免疫逃避 |
| 文章编号： | 1673-2588(2006)04-0321-04 |
| 收稿时间： | 2006-4-16 |
| 修稿时间： | 2006年4月16日 |
Progression of HLA and HPV-related tumors |
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| YANG Lan,SUN Zhen-zhu,LI Feng.Progression of HLA and HPV-related tumors[J].Journal of International Pathology and Clinical Medicine,2006,26(4):12-324. |
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| Authors: | YANG Lan SUN Zhen-zhu LI Feng |
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| Institution: | 1.Department of Pathology, College of Medicine, Shihezi University, Shihezi Xinjiang, 832002;
2.Department of Pathology, People’s Hospital of Xinjiang Uigur Autonomous Region, Urumqi 830001, China |
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| Abstract: | Human papillomavirus (HPV) infection is a high risk factor of cervical carcinoma. The pathogenesis of HPV infection is incompletely elucidated. Human leukocyte antigen (HLA) is the greatest complicated immune system. The evaluation of associations of HLA alleles with HPV variants may be helpful in designing vaccines capable of mediating immune protection against HPV infection. It can offer new clues for the etiology of carcinoma that the abnormal expressions of HLA class I，Ⅱ and Ⅲ molecules are relate to the immune escape of HPV-related carcinoma during immune response. |
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| Keywords: | HLA HPV cervical carcinoma esophageal carcinoma immune escape |
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