达英-35联合二甲双胍治疗多囊卵巢综合征的临床观察

目的分析达英-35联合二甲双胍治疗多囊卵巢综合征的临床效果。方法 56例多囊卵巢综合征患者分为观察组和对照组各28例,两组患者治疗前行血糖、激素水平检测。对照组予以达英-35,每次1片,每日1次,口服21 d后停药7 d为一疗程。观察组联合应用二甲双胍片,每次500 mg,每天3次,口服,28 d为一疗程。连续用药3个月。结果两组患者用药后痤疮有不同程度改善,多毛明显减轻,监测排卵发现不孕者中7例存在排卵,经量较治疗前增多,4例在停药3个月后自然妊娠（其中观察组3例,对照组1例）,均为足月分娩健康婴儿。两组治疗后FSH、LH、T水平均较治疗前改善明显,且观察组治疗后的FSH较对照组明显升高,而LH较对照组明显降低,观察组的T水平也较对照组明显降低（P〈0.05）。结论达英-35联合二甲双胍治疗多囊卵巢综合征较单一用药可以提高疗效、改善临床症状、增加排卵率和妊娠率,改善促排卵效果,提高妊娠率,值得临床推广和应用。

Clinical observation on Diane-35 combined with metformin in treatment of polycystic ovary syndrome

Objective To analyze the effect of Diane-35 combined with metformin in treatment of polycystic ovary syndrome.Methods In our hospital from December 2011 to December 2012,among hospitalized patients with polycystic ovary syndrome in 56 cases,according to treatment sequence were divided into observation group and control group 28 cases,two groups of patients before treatment,blood sugar,hormone levels were tested.Control group were given Diane-35,once 1 tablet,daily 1 tablet,orally 21 days after the withdrawal 7 days for a course of treatment.the observation group combined with Metformin,once 500 mg,3 times a day,orally,28 days for a course of treatment.Continuous medication for 3 months.Results The two groups of patients after treatment with different levels of acne,hirsutism significantly reduced,monitoring ovulation infertility found in 7 patients presented with ovulation,the amount of increased than before treatment,4 patients discontinued after 3 months pregnant naturally,term delivery healthy babies.After treatment,FSH,LH,T levels improved significantly than before treatment,and the level of FSH in the observation group after treatment was significantly higher than the control group,while LH was significantly lower than the control group,T levels in the observation group were also significantly lower than the control group（P 0.05）.Conclusion Diane-35 combined with metformin compared with monotherapy in treatment of polycystic ovary syndrome can improve efficacy,improve clinical symptoms,increase ovulation rate and pregnancy rate,improve ovulation effect,improve the pregnancy rate,and it is worthy of promotion and application.