头孢类抗菌药物联合其他药物致不良反应的临床评价分析

目的：探讨头孢类抗菌药物合并用药的不良反应发生情况，为临床合理用药提供参考。方法：对2006年1月～2015年1月我院收集的头孢类抗菌药物合并用药不良反应241例病例资料进行回顾性分析，调查合并用药的药品种类及合并用药前后不良反应发生情况差异。结果：头孢类抗菌药物联合用药出现不良反应的药物种类主要有水电解质和酸碱平衡调节剂、抗病毒类药物、中药注射剂、激素类药物、其他抗菌药物等；头孢类抗生素的主要不良反应以过敏反应、消化系统不良反应、神经系统不良反应较为常见，各类不良反应的发生率较用药前均显著升高（P＜0.05）。结论：头孢类抗菌药物联合其他药物使用过程中也会引发一些不良反应，临床使用过程中必须加以重视。

The analysis of the clinical evaluation of adverse reactions caused by cephalosporin antimicrobial drugs combined with other drugs

Objective:To investigate the adverse reactions caused by cephalosporin antimicrobial drugs combined with other drugs, and to provide reference for clinical rational drug. Methods:The clinical data of 241 cases of adverse reactions with cephalosporin antimicrobial drugs combined with other drugs in our hospital from January 2006 to January 2015 were retrospectively analyzed, and to investigate the differences of the merger types of drugs and drug side effects before and after treatment. Results: The main types of adverse drug reactions for the combination of cephalosporin antimicrobial drugs were water and electrolyte and acid-base balance modifiers, anti-viral drugs, traditional Chinese medicine injections, steroids, and other antimicrobial drugs. The major adverse reactions of cephalosporin were allergic reactions, digestive system adverse reactions, and nervous system adverse reaction was more common. The incidence of various types of adverse reactions were significantly higher compared than before treatment (P<0.05). Conclusion: The cephalosporin antimicrobial drugs combined with other drugs can lead to some adverse effects, and it should be pay attention in clinical application.