江苏省大丰市肺癌影响因素病例对照研究

目的探讨江苏省恶性肿瘤高发区大丰市肺癌发病的影响因素及其可能存在的交互作用。方法在大丰市进行以人群为基础、1:1匹配的肺癌病例对照研究,共调查肺癌病例和健康对照613对,通过面对面询问的方式填写调查表;采用单因素及多因素条件Logistic回归进行分析,对46个可能的肺癌影响因素,以及吸烟与饮酒、吸烟与饮茶、饮茶与饮酒之间的交互作用进行分析。结果单因素条件Logistic回归分析发现,吸烟、接触油烟、肺结核病史、饮酒、被动吸烟、江苏省启东县、海门县移民(启海移民)和性格忧郁等因素是大丰市肺癌发病的可能影响因素;调整可能混杂因素的多因素条件Logistic回归分析发现,吸烟、性格忧郁、接触油烟等为大丰肺癌的主要危险因素,相应调整OR值分别为3.198(95%CI=2.242～4.563),2.767(95%CI=1.572～4.872)和1.347(95%CI=1.007～1.800);而规律饮茶、洗晒储粮用具为该地区肺癌的保护因素,相应调整OR值分别为0.574(95%CI=0.400～0.824)和0.754(95%CI=0.573～0.993);交互作用分析则未发现明显的交互作用(P>>0.05)。结论吸烟、性格忧郁、接触油烟可明显增加大丰市人群的肺癌发病危险,规律饮茶、洗晒储粮用具等则对肺癌发病具有明显保护作用。

Case-control study on influencing factors of lung cancer in Dafeng county, Jiangsu province

ObjectiveTo explore influencing factors and potential interaction between the influencing factors of lung cancer in Dafeng county,an area with high cancer incidence in Jiangsu province,China.MethodsA population-based 1:1 matched case-control study was carried out in Dafeng county with 613 pairs of newly diagnosed lung cancer cases and health control subjects.Epidemiology data was collected by face-to-face interview using a standard questionnaire.Univariate and multivariate conditional logistic regression was applied for calculating crude odds ratio(OR)and the adjusted OR of 46 potential influencing factors of lung cancer.Potential interaction between smoking,alcohol drinking and green tea drinking on lung cancer were estimated,respectively.ResultsIn univariate conditional logistic regression analysis,smoking,frequent exposure to cooking fume,history of pulmonary tuberculosis,alcohol drinking,environmental tobacco smoking(ETS),the immigrants from Qidong and Haimen County,melancholy temperament,frequently washing grain containers and regularly green tea drinking were found to be the potential influencing factors of lung cancer.In multivariate conditional logistic regression analysis,smoking,melancholy temperament and frequent exposure to cooking fume were found to be the risk factors of lung cancer with adjusted OR of 3.198(95% confidence interval(CI)=2.242-4.563),2.767(95% CI=1.572- 4.872)and 1.347(95% CI=1.007-1.800),respectively.Regular green tea drinking and frequently washing grain container were found inversely associated with lung cancer risk in Dafeng county with the adjusted OR of 0.574(95% CI= 0.400-0.824)and 0.754(95% CI=0.573-0.993),respectively.No significant interaction was found between smoking, alcohol drinking and green tea drinking on lung cancer risk.ConclusionSmoking,melancholy temperament and frequent exposure to cooking fume could significantly increase the risk of lung cancer in Dafeng county.Regulary green tea drinking and frequently washing grain containers may reduce the risk of lung cancer in the area.