| KAI1和CD44v6蛋白在骨肉瘤组织中的表达及临床意义 |
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| 作者单位： | Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| 摘 要： | ![]()
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| 关 键 词： | CD44v6蛋白 KAI1基因 人骨肉瘤 临床意义 Enneking CD44v6表达 外科分期系统 Cox模型分析 |
The expression and clinical significance of KAI1 and CD44v6 protein in human osteosarcoma |
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| Weihua Hu,Anmin Chen,Fengjing Guo,Feng Li. The expression and clinical significance of KAI1 and CD44v6 protein in human osteosarcoma[J]. The Chinese-German Journal of Clinical Oncology, 2009, 8(4): 232-236. DOI: 10.1007/s10330-009-0024-8 |
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| Authors: | Weihua Hu Anmin Chen Fengjing Guo Feng Li |
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| Affiliation: | Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | ![]()
Objective: To investigate the expressions of KAI1 and CD44v6 in human osteosarcoma and the relationship between expressions of them and their clinic pathological features and prognosis. Methods: The expressions of KAI1 and CD44v6 in 87 samples with osteosarcema were detected by S-P immunohistochemistry. Results: Expression of KAI1 had correlation with metastasis of osteosarcoma, and was strongly associated with differentiation of tumor cells. The expression of CD44v6 in osteosarcoma had correlation with metastasis. There was no difference between the expression of KAI1 and CD44v6. Cox model analysis showed that the prognostic factors were KAI1 expression, metastasis and Enneking surgical staging system. Conclusion: The abnormal expression of KAI1 and CD44v6 participate metastasis of osteosarcoma, KAI1 expression, metastasis and Enneking surgical staging system can be used to independently predict the prognosis of osteo-sarcoma patients. |
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| Keywords: | KAI1 CD44v6 osteosarcoma metastasis |
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