| 重组人生长激素降解产物的检测分析 |
| |
| 引用本文： | 张培培,杨化新.重组人生长激素降解产物的检测分析[J].药物分析杂志,1994,14(5):17-21. |
| |
| 作者姓名： | 张培培 杨化新 |
| |
| 作者单位： | 中国药品生物制品检定所 |
| |
| 摘 要： | 本文详细介绍了Ｓ－Ｂ电导率模型确定泥质砂岩储层含水饱和度的基本原理以及相应参数的确定方法。用该方法处理了大庆地区的树１３１井、萨南５丁４－检１３２井及杏９丁３检１３４井的一些层位，并将求得的含水饱和度与岩心分析的含水饱和度进行了对比，吻合得比较好。这说明了应用Ｓ－Ｂ模型确定储层的含水饱和度是可行的，结果比较好。
|
| 关 键 词： | γ－hGH 降解产物 检测 |
Detection of Degradation Products of r-hGH |
| |
| Zhang Peipei, Yang Huaxin and Xu Kangsen.Detection of Degradation Products of r-hGH[J].Chinese Journal of Pharmaceutical Analysis,1994,14(5):17-21. |
| |
| Authors: | Zhang Peipei Yang Huaxin and Xu Kangsen |
| |
| Institution: | National Institute for the Control of Pharmaceutical and Biological Products |
| |
| Abstract: | Methods in this publication were examined for the detection of degradation products of recombinant human growth hormone (r-hGH). The analytical procedures involved RP-HPLC.isoelectric focusing (IEF), polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS-PAGE), hydrophobicinteraction chromatography (HIC) and high performance size-exclusion chromatography (HPSEC). The degration reactions product identified using these techniques were those of deamination, proteolysis, aggregation and so on. It showed that each of the various forms of growth hormone produced with respect to different degradation processes could be separated by at least one of the above mentioned analytical techniques. |
| |
| Keywords: | r-hGH degradation products SDS-PAGE IEF RP-HPLC HIC HPSEC |
| 本文献已被 CNKI 维普 等数据库收录！ |
