| 重组人生长激素胰肽图谱分析 |
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| 引用本文： | 杨化新,张培培.重组人生长激素胰肽图谱分析[J].药物分析杂志,1994,14(3):10-13. |
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| 作者姓名： | 杨化新 张培培 |
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| 作者单位： | 中国药品生物制品检定所 |
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| 摘 要： | 本文采用ＲＰ－ＨＰＬＣ法检测国内外重组人生长激素经胰蛋白酶裂解的肽片段，并与天然人生长激素对比，肽图谱分析的结果表明，重组人生长激素与其天然产物的分子结构具有同一性，国内各批产品的蛋白质一级结构具有一致性。ＨＰＬＣ胰肽图谱分析为基因工程多肽药物的质量控制提供了一种有效手段。
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| 关 键 词： | 胰肽图谱分析 r－hGH 生长激素 |
HPLC Analysis of Tryptic Mapping of Recombinant Human Growth Hormone |
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| Yang Huaxing, Zhang Peipei and Xu Kangsen.HPLC Analysis of Tryptic Mapping of Recombinant Human Growth Hormone[J].Chinese Journal of Pharmaceutical Analysis,1994,14(3):10-13. |
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| Authors: | Yang Huaxing Zhang Peipei and Xu Kangsen |
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| Institution: | National Institute for the Control of Pharmaceutical and Biological Products 100050 |
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| Abstract: | HPLC-tryptic mapping of r-hGH were analysed and compared with nature hGH. The results show that molecular structure r-hGH and nGH are identical, r-hGH made in China has lot-to-lot consistency of primary structure (within the limites of this technique). This technique is an effecient tool for the quality control biotechnology -derived pharmaceutical products. |
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| Keywords: | r-hGH RP-HPLC tryptic-mapping |
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