Protective Effect of Vaccination with a Combination of Recombinant Surface Antigen 1 and Interleukin-12 against Toxoplasmosis in Mice |
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| Authors: | Valerie Letscher-Bru Odile Villard Bernhard Risse Michael Zauke Jean-Paul Klein Truong T. Kien |
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| Affiliation: | Institut de Parasitologie et de Pathologie Tropicale, Inserm U392, Faculté de Médecine,1. and Faculté de Pharmacie,3. 67000 Strasbourg, France, and Roche Diagnostics, Basel, Switzerland2. |
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| Abstract: | ![]()
We studied the immune response induced in mice by recombinant Toxoplasma gondii surface antigen 1 (rSAG1) protein, alone or combined with interleukin-12 (IL-12) as an adjuvant, and the protective effect against toxoplasmosis. Immunization with rSAG1 alone induced a specific humoral type 2 immunity and did not protect the animals from infection. In contrast, immunization with rSAG1 plus IL-12 redirected humoral and cellular immunity toward a type 1 pattern and reduced the brain parasite load by 40%. |
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