盐酸多奈哌齐治疗轻、中型脑外伤后认知障碍的临床研究

目的探讨盐酸多奈哌齐对轻、中型脑外伤患者伤后认知障碍及临床预后的影响。方法本组轻、中型脑外伤合并认知障碍患者78例,随机分成治疗组和对照组,治疗组应用盐酸多奈哌齐,对照组应用吡拉西坦,两组的治疗周期为12周。治疗前及治疗后分别应用简明精神状态检测量表（MMSE）、国人修订成人韦氏智力量表（WAIS-RC）和格拉斯哥预后评分（GOS）评价疗效。结果两组治疗后12周MMSE和WAIS-RC评分均较治疗前提高（P〈0.05）。治疗组MMSE和WAIS-RC评分提高较对照组明显（P〈0.05）,治疗组GOS预后优良率优于对照组（P〈0.05）。结论盐酸多奈哌齐对轻、中型脑外伤后认知障碍有积极治疗作用,并能改善临床预后。

Theraputic effects of donepezil on the cognitive impairment following light and moderate traumatic brain injury

Objective To investigate the therapeutic effects of donepezil on the cognitive impairment and clinical prognosis after light and moderate traumatic brain injury(TBI).Method 78 patients with cognitve impairment following light and moderate TBI were randomly divided into therapy and control group.The therapy group used donepezil and the control group applied the piracetan for 12 weeks.All patients were assessed with Mini Mental State Examination(MMSE),Wechsler Adult Intelligence Tevised in China(WAIS-RC),and Glasgow Prognosis Score before and after the treatment.Results Both MMSE and WAIS-RC scores are improved in the two groups after treatment.Scores improved significantly on MMSE and WAIS-RC than control group after the treatment(P<0.05),and clinical prognosis were also significantly improved after the treatment(P<0.05).Conclusions Donepezil can significantly improve the cognitive impairment and clinical prognosis following light and moderate TBI.