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| 假性囊膜剥脱综合征发病机制研究进展 | |
| 引用本文： | 曹婷婷,;鲍永珍. 假性囊膜剥脱综合征发病机制研究进展[J]. 眼科研究, 2014, 0(10): 950-953 |
| 作者姓名： | 曹婷婷, 鲍永珍 |
| 作者单位： | [1]北京大学人民医院眼科、教育部视觉损伤与修复重点实验室,100044; [2]河北省沧州市中心医院眼科,100044; |
| 摘 要： | 假性囊膜剥脱综合征（PEX）是一种以纤维状剥脱物广泛沉积于眼部及全身其他组织为特征的年龄相关性疾病，在发病过程中可加速白内障的进展，部分患者可继发青光眼。目前研究表明，PEX的发病与基底膜损伤、自身免疫功能紊乱以及遗传因素相关，但确切的发生机制至今尚未明确。就PEX的组织病理学特点及发病机制的研究进展进行综述，以期有助于PEX的预防与治疗。 |
| 关 键 词： | 假性囊膜剥脱综合征 发病机制 基底膜学说 免疫学说 遗传学说 |
Progress of pathogenesis research on pseudoexfoliation syndrome |
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| Affiliation: | Cao Tingting, Bao Yongzhen(Peking University People′s Hospital ,Key Laboratory of Vision Loss and Restoration ,Ministry of Education Key ,Beijing 100044, China) |
| Abstract: | Pseudoexfoliation syndrome （PEX） is an age-related systemic disease,with the features of fibrous stripped content widely deposit on the eye and other systemic organizations,which is associated with a rapid progress of cataract and secondary glaucoma in partial patients. The present study showed that the basement membrane injury, autoimmune disorders,and genetic factors were related to PEX,but the exact pathogenesis of PEX is still unclear. The purpose of this review was to discuss the recent progress in the pathogenesis and histopathology, expecting to contribute to the prevention and treatment of PEX. |
| Keywords: | Pseudoexfoliation syndrome Pathogenesis Theory of basement membrane Immunologicaltheory Theory of heredity |
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