盐酸米诺环素缓释药条用于成人牙周炎辅助治疗的疗效观察

目的 评价盐酸米诺环素缓释药条用于成人牙周炎辅助治疗的临床效果。方法 采用单盲随机法，选择成人牙周炎患16例，126个BOP( )位点，探诊深度＞5mm。基础治疗后，随机分为两组，试验组为盐酸米诺环素缓释药条组，对照组则为龈下刮治组。试验组每周于牙周袋内上药1次，共6周。第0、4、6、12周观察PD、AL、BOP临床指标。结果 试验组各临床指标改善均优于对照组。结论 盐酸米诺环素缓释药条用于成人牙周炎辅助治疗是有效的。

Clinical Effects of Minocycline- HCl Local Drug Delivery as an Adjunct to Conventional Therapy for Adult Periodontitis

Objective This study was designed to evaluate the clinical effects of minocycline-HCl local drugdelivery as an adjunct to conventional therapy for adults with periodontitis. Methods this was a randomized single-blinded study. 16 adult patients with periodontitis who had at least 5 mm of PD and 126 BOP positive sites were selected .After conventional therapy, the subjects were randomly divided into two groups ,one of which was the test group treated with minocycline-HCl local drug delivery, and the other was the control group treated with scaling and root planing .The test drug were applied with an applicator into the periodontal pockets once a week for 6 weeks. Clinical parameter including PD, AL and BOP was recorded after 0,4,6,12 weeks'' observation respectively. Results All clinical parameters from test group were better than those from control group. Conclusion It indicates local application with minocycline-HCl local drug delivery as an adjunct to conventional therapy may lead to a more advantageous outcome for adult patieuts with periodontitis.