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| FS-1272滴眼液对糖性白内障大鼠晶状体抗氧化系统的影响 | |
| 引用本文： | 郑洁珍,周大兴,彭少华,朱晓燕,顾静,王晶. FS-1272滴眼液对糖性白内障大鼠晶状体抗氧化系统的影响[J]. 浙江中医药大学学报, 2008, 32(1): 44-45 |
| 作者姓名： | 郑洁珍 周大兴 彭少华 朱晓燕 顾静 王晶 |
| 作者单位： | 浙江中医药大学药学院,杭州,310053 |
| 基金项目： | 上海新药研究开发中心横向课题(No:65086)~~ |
| 摘 要： | [目的]探讨FS-1272滴眼液对大鼠D-半乳糖性白内障的作用机理。[方法]采用大鼠D-半乳糖性白内障模型,测定晶状体中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱苷肽过氧化酶(GSH-px)、丙二醛(MDA)含量。[结果]FS-1272滴眼液能提高SOD、CAT、GSH-px活性,同时降低MDA含量。[结论]FS-1272滴眼液可减轻晶状体氧化损伤程度,从而起到延缓白内障发生和发展的作用。 |
| 关 键 词： | 白内障 D-半乳糖 超氧化物歧化酶 过氧化氢酶 丙二醛 谷胱苷肽过氧化酶 |
| 文章编号： | 1005-5509(2008)01-0044-02 |
| 修稿时间： | 2007-12-21 |
Effects of FS-1272 Gutta on Anti-oxidative System in Lens of Rats with Cataract Induced by D-galactose |
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| Zheng Jiezhen,Zhou Daxing,Peng Shaohua,et al Zhejiang University of Traditional Chinese Medicine,Hangzhou. Effects of FS-1272 Gutta on Anti-oxidative System in Lens of Rats with Cataract Induced by D-galactose[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2008, 32(1): 44-45 | |
| Authors: | Zheng Jiezhen Zhou Daxing Peng Shaohua et al Zhejiang University of Traditional Chinese Medicine Hangzhou |
| Abstract: | [Objective] To discuss mechanism of FS-1272 eye drops on cataract of rats induced by D-galactose.[Method]By using the model of cataract of rats induced by D-galactose to determine the content of SOD,CAT,GSH-px,MDA in lens.[Result]FS-1272 eye drops can increase the activities of SOD,CAT,GSH-px and decrease the content of MDA.[Conclusion]FS-1272 eye drops have the effect of delaying the generation and development of cataract by alleviating the extent of oxidative injury of lens. |
| Keywords: | cataract D-galactose SOD MDA CAT GSH-px |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |