三阴性乳腺癌578例临床病理特点及预后分析

目的 探讨女性三阴性乳腺癌(TNBC)的临床病理特点及影响预后因素.方法 回顾性分析中国医学科学院肿瘤医院外科1990 年12 月至2008 年12 月收治的578 例TNBC 资料.结果 578 例TNBC 占同期乳腺癌的18.6%,全组患者均经手术治疗,病理类型以浸润性导管癌为主(86.0%).全组总的5 年及10 年生存率分别为75.6%和56.3%.单因素分析显示年龄、组织学分化程度、脉管瘤栓、N 分期、T 分期以及TNM 分期是影响预后的主要因素(P ＜0.05).多因素分析显示组织学分化程度、淋巴结状态是影响预后的独立因素.结论 TNBC 具有较强的侵袭性,预后较差,淋巴结状况和组织学分化程度是影响TNBC 预后的独立因素.

Clinicopathological characteristics and prognosis of women with triple negative breast cancer

Objective To study clinicopathological characteristics and prognosis of triple negative breast cancer（TNBC）.Methods The data of 578 patients with TNBC treated at the Cancer Hospital of Chinese Academy of Medical Sciences from December 1990 to December 2008 was analyzed retrospectively.Results 578（18.6%）were confirmed to be TNBC.Curative resection was performed for all patients,major pathological type was invasive ductal carcinoma（86.0%）.The overall 5-and 10-year survival rates were 75.6% and 56.3%,respectively.Univariate analysis showed that age,histological grade,invading vessels,lymph node status,T stage,and TNM stage were statistically significant（P0.05）.The multivariate analysis showed lymph node status and histological grade were independent prognostic factors.Conclusions TNBC is more aggressive.Patients with TNBC suffer from poor prognosis.Lymph node status and histological grade are independent prognostic factors.