Neutrophil priming by hepatocyte growth factor, a novel cytokine. |
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| Authors: | W Jiang M C Puntis T Nakamura M B Hallett |
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| Affiliation: | University Department of Surgery, University of Wales College of Medicine, Cardiff, U.K. |
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| Abstract: | We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils. |
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