| 肿瘤转移抑制因子CD82/KAI1基因在小鼠子宫内膜的动态表达 |
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| 引用本文： | 王焕英,谭冬梅,何明忠,王立芝,谭毅. 肿瘤转移抑制因子CD82/KAI1基因在小鼠子宫内膜的动态表达[J]. 生殖与避孕, 2007, 27(1): 16-20 |
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| 作者姓名： | 王焕英 谭冬梅 何明忠 王立芝 谭毅 |
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| 作者单位： | 1. 重庆医科大学,实验动物中心,重庆,400016
2. 重庆医科大学,实验动物中心,重庆,400016;重庆医科大学,临床检验诊断学重庆市重点实验室,重庆,400016 |
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| 基金项目： | 国家自然科学基金;重庆市自然科学基金 |
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| 摘 要： | 目的：探讨肿瘤转移抑制因子CD82/KAI1在小鼠胚胎着床过程中的功能。方法：应用RT-PCR和免疫组织化学技术分别观察CD82/KAI1mRNA和蛋白在小鼠动情周期和早孕子宫中的表达。结果：在动情周期中,CD82/KAI1mRNA除在动情期较低外,其余三期的表达量基本相同,但蛋白质却是在动情期表达最丰富,子宫内膜上皮和基质均呈阳性。在早孕子宫中,CD82/ KAI1mRNA的表达逐渐增多,蛋白质表达的量和范围也逐渐增强。结论：CD82/KAI1在小鼠子宫中呈动态表达,提示它在胚胎精确侵袭子宫内膜的调节中发挥作用。
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| 关 键 词： | 肿瘤转移抑制因子CD82/KA11 子宫内膜 胚胎着床 |
| 文章编号： | 0253-357X(2007)01-0016-05 |
| 修稿时间： | 2006-10-30 |
Spatiotemporal Expression of Tumor Metastasis Inhibitory Factor CD82/KAI1 Gene in Mouse Uterine Endometrium |
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| Huan-ying WANG,Dong-mei TAN,Ming-zhong HE,Li-zhi Wang,Yi TAN. Spatiotemporal Expression of Tumor Metastasis Inhibitory Factor CD82/KAI1 Gene in Mouse Uterine Endometrium[J]. Reproduction and Contraception, 2007, 27(1): 16-20 |
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| Authors: | Huan-ying WANG Dong-mei TAN Ming-zhong HE Li-zhi Wang Yi TAN |
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| Affiliation: | l. Laboratory Animal Center, 2. Key Laboratory of Laboratory Medical Diagnostics in Chongqing, Chongqing Medical University, Chongqing, 400016 |
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| Abstract: | Objective:To explore the function of tumor metastasis suppressor genes CD82/KAI1 during the process of embryonic implantation in mouse.Methods:Protein and mRNA expression of tumor metastasis suppressor genes CD82/KAI1 were detected by immunohistochemistry and RT-PCR.Results:During estrous cycle, CD82/KAI1 mRNA was expressed much lower in estrus,while it had the similar expression in other three periods. However,protein was expressed most abundantly in estrus,and endometrial epithelial cells and stroma cells showed strongly positive.In the mouse uterus of early pregnancy,mRNA expression of CD82/KAI1 gradually increased day by day,and protein expression of CD82/KAI1 also gradually increased in quantity and range as well. Conclusion:Spatiotemporal expression of CD82/KAI1 in mouse uterus showed that it might play roles in regulating precise invasion embryo into uterine endometrium. |
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| Keywords: | CD82/KAI1 uterine endometrium embryo implantation |
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