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| 转化生长因子β_1抗体促进大鼠周围神经再生的实验研究 | |
| 引用本文： | 安奇君,刘强. 转化生长因子β_1抗体促进大鼠周围神经再生的实验研究[J]. 实用口腔医学杂志, 2006, 34(7): 590-592 |
| 作者姓名： | 安奇君 刘强 |
| 作者单位： | 山西省人民医院，山西医科大学第一医院 030012 |
| 摘 要： | 目的评价局部应用外源性转化生长因子β1(TGF-β1)抗体对端端吻合神经远端再生的影响。方法选用雄性SD大鼠48只,随机分为2组,TGF-β1组和生理盐水对照组各24只;行坐骨神经切断吻合术,切口分别注入TGF-β1抗体和生理盐水各30μL;术后4,12周取材进行大体观察及电生理、超微结构和病理学染色检测。结果12周时神经电生理检查,4,12周行MESSION染色、电镜等方面均显示实验组神经再生均优于对照组。结论TGF-β1抗体对大鼠神经再生有明显促进作用。 |
| 关 键 词： | 转化生长因子β 坐骨神经 神经再生 |
| 收稿时间： | 2006-04-05 |
| 修稿时间： | 2006-04-05 |
Effects of anti-transforming growth factor-beta1 on peripheral nerve regeneration in rats |
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| AN Qi-jun,LIU Qiang. Effects of anti-transforming growth factor-beta1 on peripheral nerve regeneration in rats[J]. Journal of Practical Stomatology, 2006, 34(7): 590-592 | |
| Authors: | AN Qi-jun LIU Qiang |
| Abstract: | Objective To evaluate the effects of a topical application of exogenous transforming growth factor(TGF)-β_1 antibody on the neural regeneration.Methods Forty-eight male SD rats were divided into two groups at random.Twenty-four rats were as control group with 30 μL normal saline inlet into stomach,the experimental effects was compared with another 24 rats(experimental group) with 30 μL TGF-β_1 antibody inlet into stomach.Each group was researched through general observation,electrophysiology,ultrastructural structure and pathologic staining.Results The results of the neural electrophysiologic study after 12 weeks showed that the neural regeneration of the experimental control was superior to that of control group by microscope,etc.after 4 weeks.Conclusion TGF-β_1 antibody obviously promotes rats′ neural regeneration. |
| Keywords: | Transforming growth factor-beta Sciatic nerve Nerve regeneration |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |