婴幼儿重症肺炎支原体肺炎的临床和免疫功能研究

目的 探讨婴幼儿重症肺炎支原体肺炎（MPP）临床和免疫功能变化。方法 采用酶联免疫法（ELISA）检测35例MPP患儿肺炎支原体（MP）特异IgM、IgA，速率散射比浊法测定免疫球蛋白IgG及其亚类，荧光法检测T细胞亚群，并对临床表现和实验室结果进行分析，选取同期健康婴幼儿42例作为对照组。结果 重症MPP组患儿的CD3^＋、CD4^＋细胞数，CD4^＋／CD8^＋和C3含量小于对照儿，而IgA、IgM、循环免疫复合物（CIC）、CD8^＋细胞数高于对照儿，差别有非常显著性意义（P〈0．01）．IgG及亚类间差别无显著性意义（P〉0．05）。结论 重症MP感染患儿免疫功能的变化主要表现为CD3^＋、CD4^＋受抑，免疫功能低下可能是导致其发病的原因之一。

A Study of Clinical and Immunological Function on Infants' Infectious Mycoplasma Pneumonia

Objective To explore the change of the clinical manifestation and immunological function of infectious mycoplasma pneumonia in Duyun area.Methods The serum specimens were collected from 35 infants with infectious mycoplasma pneumonia,mycoplasmal specific serum IgM and IgA antibodies were detected by enzyme linked immunosorbent assay(ELISA),total IgG and its subelasses were determined by rate scattered nephelometry;T-lymphocyte subpopulations were detected by fluorimetry method,and clinical and other laboratory data were analyzed.Results The immune status,CD_3,CD_4 cell counts and C3 levels of infants with mycoplasma pneumonia were lower than those of the controls while their serum IgA,IgM concentrations and circulating immune complex levels were higher than those of the control(P<0.01).The concentration of serum was IgG and IgG1-4 between mycoplasma pneumonia group and the control group.Conclusion The immunological changes of infants suffered from infectious mycoplasma pneumonia included declined CD_3 and CD_4 cell counts.The lower immunological function may be one of the causes of mycoplasma pneumonia.