| 益气凉血解毒类中药对拉米夫定诱发乙肝病毒YMDD变异的干预作用 |
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| 引用本文： | 徐春军,刘燕玲,李秀惠,戚团结,刘敏,林凌云.益气凉血解毒类中药对拉米夫定诱发乙肝病毒YMDD变异的干预作用[J].中华中医药杂志,2008,23(12):1079-1081. |
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| 作者姓名： | 徐春军 刘燕玲 李秀惠 戚团结 刘敏 林凌云 |
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| 作者单位： | [1]首都医科大学附属北京中医医院肝病科,北京100010 [2]中国中医科学院西苑医院肝病科,北京100091 [3]首都医科大学附属北京佑安医院中西医结合科,北京100054 |
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| 基金项目： | 国家中医药管理局中医药科学技术研究专项 |
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| 摘 要： | 目的:观察益气凉血解毒类中药对慢性乙型病毒性肝炎抗病毒治疗及其耐药株发生率的影响.方法:选择慢性乙型病毒性肝炎患者138例,随机分为3组.分别予以口服拉米夫定、拉米夫加益气凉血解毒类中药和单纯益气凉血解毒类中药治疗,疗程均为12个月,分别观察肝功能、HBVM指标、HBV-DNA、YMDD和临床症状的变化.结果:3组在治疗后临床症状均明显改善,ALT、AST、HBV.DNA均降低,有明显统计学意义(P＜0.05).治疗后3组间各指标无明显差异(P＞0.05).结论:益气凉血解毒类中药可以对拉米夫定诱发的乙型肝炎病毒YMDD变异起列明显的抑制作用,且对慢性乙型病毒性肝炎有明显疗效.
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| 关 键 词： | 慢性乙型病毒性肝炎 益气凉血解毒类中药 抗病毒治疗 YMDD变异 临床研究 |
Study on interference effect of Chinese drugs of Yiqi Liangxue Jiedu on YMDD variation of HBV induced by lamivudine |
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| XU Chun-jun,LIU Yan-ling,LI Xiu-hui,QI Tuan-jie,LIU Min,LIN Ling-yun.Study on interference effect of Chinese drugs of Yiqi Liangxue Jiedu on YMDD variation of HBV induced by lamivudine[J].China Journal of Traditional Chinese Medicine and Pharmacy,2008,23(12):1079-1081. |
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| Authors: | XU Chun-jun LIU Yan-ling LI Xiu-hui QI Tuan-jie LIU Min LIN Ling-yun |
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| Institution: | XU Chun-jun1,LIU Yan-ling2,LI Xiu-hui3,QI Tuan-jie1,LIU Min1,LIN Ling-yun1(1Department of Hepatopathy,Beijing TCM Hospital of Capital Medical University,Beijing 100010,China,2Department of Hepatopathy,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,3Department of Integrated Traditional , Western Medicine,Beijing YouAn Hospital of Capital Medical University,Beijing 100054,China) |
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| Abstract: | Objective:To investigate the effect of Chinese drugs of Yiqi Liangxue Jiedu on chronic hepatitis B and the incidence of drug-resistant strains.Methods:138 patients with chronic hepatitis B were divided randomly into 3 groups:oral administration lamivudine group,oral administration lamivudine and Chinese herb of Yiqi Liangxue Jiedu group,and oral administration Chinese drugs of Yiqi Liangxue Jiedu group.The treatment course of 3 groups was 48 weeks.Liver function,HBV-DNA and variation of YMDD were observed a... |
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| Keywords: | Chronic hepatitis B Chinese drugs of Yiqi Liangxue Jiedu Antiviral therapy Variation of YMDD Clinical research |
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