血管内皮生长因子在上皮性卵巢癌组织中的表达及意义

目的探讨血管内皮生长因子（VEGF）在上皮性卵巢癌（EOC）中的表达及其在EOC发生发展、预后中的意义。方法用免疫组织化学法检测10例正常卵巢组织、20例良性上皮性卵巢肿瘤（EOT）组织以及50例EOC组织中VEGF的表达情况,并分析其表达和EOC临床病理因素以及预后之间的相关性。结果 VEGF在EOC组织的阳性表达率（82.0%）明显高于良性EOT组织（45.0%）和正常卵巢组织（30.0%）,同时EOC组织中VEGF表达与临床分期、分化程度及其淋巴结转移之间存在明显的相关关系（P〈0.05）。进一步分析显示,VEGF阳性表达者的复发率高于阴性表达者,而5年复发时间明显短于阴性表达者（P〈0.05）。结论 VEGF表达与EOC的发生发展有关,对EOC患者是一个有价值的预后因素。

Expression of vascular endothelial growth factor in epithelial ovarian carcinoma and its clinical significances

Objective To explore correlations between vascular endothelial growth factor （VEGF） expression and clinicopathological factors in epithelial ovarian carcinoma （EOC） and analyze the significance of VEGF expression in prognosis of patients with EOC.Methods The expression of VEGF in normal ovaries tissues （n=10）,benign epithelial ovarian tumor （EOT） tissues （n=20） and EOC tissues （n=50） were detected by the immunohistochemistry method.The correlations among VEGF expression and clinicopathological factors,prognostic parameters were analyzed.Results The positive rates of VEGF expression （82.0%） were higher in EOC tissues than those in benign EOT tissues （45.0%） and normal ovaries tissues （30.0%）,and VEGF expression was significant correlated with clinical stage,differentiation degree and lymph node metastasis in EOC tissues （P0.05）,Further analysis showed that the recurrence rate was higher and the five-year recurrence time was shorter in patients with positive for VEGF than in those with negative for VEGF （P0.05）.Conclusion VEGF expression is closely associated with the occurrence and development of EOC.VEGF expression is valuable parameters for predicting the prognosis of patients with EOC.