572例入园、托儿童乙肝疫苗免疫效果分析

目的了解入园、托儿童乙肝表面抗原携带情况和乙肝疫苗免疫效果,为低龄儿童的乙肝防治提供参考依据。方法运用双抗原夹心时间分辨免疫荧光分析法（IFMA法）测定样本HBsAg和HBsAb浓度值,应用统计软件SAS进行数据分析。结果乙肝表面抗原阳性率为0.69%;乙肝表面抗体阳性率为68.53%,男女差异无统计学意义。随年龄增长;儿童抗-HBs滴度和抗-HBs阳性率下降（P〈0.01）。结论乙肝疫苗免疫效果随免疫年限的增长而渐弱,无性别差异。接种乙肝疫苗后定期应检验接种效果,以便及时加强免疫。

Analysis on immune effect of vaccine HB of 572 kindergarten kids

Objective To learn the HBsAg and immune effect of the kindergarten kids and to provide the reference of HB prevention of the kids of lower ages.Methods By using IFMA,we can detect the antiboby concentration of HBsAg and HBsAb and conduct data analysis by SAS.Results The rate of HBsAg negative is 0.69%,while the rate of HBsAb is 68.53% and there is no difference between male and female.With increase of age,the HBsAb titer and positive rate is decreasing （P0.01）.Conclusion The HB immune effect is decreasing with the increase in age.There is no difference between genders.After HB vaccination,it is advisable to check the immune effect in order to give the boost dose in time.