Electron Microscopy of the Red Cells in Erythropoietic Porphyria

With the aid of electron microscopy two different red cell lines have beenidentified in erythropoietic porphyria. A normal red cell series has been foundin association with hemoglobin containing normoblastic nuclei and ferritinladen reticulocytes. The abnormal line presumably represents the porphyrincontaining cells. A possible explanation to account for the abnormality inheme synthesis has been proposed.

Submitted on February 24, 1964 Accepted on April 17, 1964