An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese |
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| Authors: | J. Y. Zhao M. M. Xiong W. Huang H. Wang J. Zuo G. D. Wu Z. Chen B. Q. Qiang M. L. Zhang J. L. Chen W. Ding W. T. Yuan H. Y. Xu L. Jin Y. X. Li Q. Sun Q. Y. Liu E. Boerwinkle F. D. Fang |
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| Affiliation: | (1) Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 100005 Beijing, China;(2) Human Genetics Center, University of Texas-Houston, Houston, TX 77225, USA;(3) Chinese National Human Genome Center at Shanghai, 201203 Shanghai, China;(4) Department of Endocrinology, Peking Union Medical College Hospital, 100730 Beijing, China;(5) Chinese National Human Genome Center at Beijing, 100005 Beijing, China;(6) Shanghai Institute of Endocrinology, 200025 Shanghai, China;(7) Ruijin Hospital, Shanghai Second Medical University, 200025 Shanghai, China;(8) Morgan-Tan International Center for Biological Sciences, Fudan University, 200433 Shanghai, China |
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| Abstract: | We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1–5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses. |
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| Keywords: | Type 2 diabetes Whole-genome scan Linkage analysis |
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