Visual versus computer evaluation of thiopental-induced EEG changes in temporal lobe epilepsy |
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| Authors: | J P Lieb M R Sperling J R Mendius C E Skomer J Engel |
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| Affiliation: | 1. Department of Anesthesiology, Columbia University, New York, NY, USA;2. Department of Anesthesiology and Intensive Care, Technical University of Munich School of Medicine, Munich, Germany;3. Department of Anaesthesiology, Waikato Clinical School, University of Auckland, Hamilton, New Zealand;4. Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;1. Department of Psychiatry, Hacettepe University Medical Faculty, Turkey;2. Faculty of Psychology and Neuroscience, Brain Stimulation and Cognition Research Group, Maastricht University, The Netherlands;3. Department of Biostatistics, Hacettepe University Medical Faculty, Turkey;1. School of Environmental Engineering, University of Seoul, Seoul 02504, Republic of Korea;2. Clean Energy Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea;3. Division of Energy & Environment Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea;4. Department of Environmental Engineering, Sunchon National University, Suncheon 57922, Republic of Korea;5. Department of Chemical Engineering, Kongju National University, Cheonan 31080, Republic of Korea;1. Perugia University, S.Maria della Misericordia Hospital, S. Andrea delle Fratte, Perugia, Italy;2. University Hospital, Modena, Italy;3. Portogruaro Hospital, Venezia, Italy;4. Second University of Naples, Italy |
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| Abstract: | ![]()
Thiopental-induced EEG beta activity was analyzed both visually and by computer in 33 patients with complex partial epilepsy. Studies were done in 16 patients with depth electrodes in limbic structures and 17 patients with scalp and sphenoidal electrodes. The percentage of drug-induced change in beta activity was quantified by computer using spectral analysis. The statistical significance of asymmetries between homologous sites in the amount of change was determined. The spatial distribution of significant asymmetries was used for localization and compared with the results of independent visual analysis of the thiopental EEG. Concordance between computer and visual evaluation occurred in 10 of 17 scalp/sphenoidal and 10 of 16 depth electrode tests. The accuracy of visual and computer localization was determined by comparing them with locus of itcal EEG onset, interictal spikes, and positron emission tomography. In scalp/sphenoidal studies, computer analysis indicating asymmetry appeared more likely to correlate with independent clinical criteria than visual analysis. In depth studies the reverse appeared to be true. Scalp/sphenoidal tests yielded positive results in 25-30% of patients whereas depth electrode tests were positive in 50-70% of patients. The results indicate that computer analysis of surface thiopental tests is an accurate and useful supplement to visual evaluation of these tests. |
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