瑞舒伐他汀与阿托伐他汀治疗冠心病的效果对比观察

目的 比较瑞舒伐他汀与阿托伐他汀治疗冠心病的临床效果.方法 随机将128例在本院心内科住院的冠心病患者分为观察组和对照组各64例,观察组每晚给予瑞舒伐他汀10 mg服用,对照组每晚给予同等剂量的阿托伐他汀服用,连续21 d后观察比较两组患者治疗前后血脂情况的变化和安全情况.结果 治疗后两组血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）均较治疗前降低,观察组高密度脂蛋白胆固醇（HDL-C）水平较治疗前升高,差异有统计学意义（P＜0.05）,且观察组血脂水平改善程度优于对照组（P＜0.05）.观察组总有效率为95.3％,对照组总有效率为87.5％,观察组总有效率明显高于对照组（P＜0.05）.观察组不良反应发生率明显低于对照组（P＜0.05）.结论 在同等剂量下,瑞舒伐他汀的调脂效果和安全情况显著高于阿托伐他汀.

Efficacy comparision of rosuvastatin and atorvastatin on treating coronary heart disease

Objective To observe the clinical efficacy of rosuvastatin and atorvastatin on treating coronary heart disease （CHD）.nethods 128 cases of patients with CHD in our hospital were divided into observation group and control group, the observation group was treated by 10 mg oral rosuvastatin every night,the control group was treated by 10 mg ator- vastatin every night,21 days later, changes of blood lipid level and security in two groups before and after treatment was observed and compared.Results After treatment,TC,TG and LDL-C of two groups decreased, and HDL-C of observation group increased compared with before treatment,the difference was significant （P〈0.05）.In observation group,the im- provement of blood lipid was significantly better than that of control group （P〈0.05）.The total effective rate of observa- tion group （95.3%） was significantly higher than 87.5% of control group （P〈0.05）.The incidence of adverse reactions of observation group was significantly lower than that of control group （P〈0.05）.Conclusion Rosuvastatin has better effect on lipid regulation and higher security compared with atorvastatin in the same dose.