同步放化疗治疗中晚期中上段食管癌的临床观察

目的 探讨并分析同步放化疗治疗中晚期中上段食管癌的近期疗效及不良反应.方法 选取2007年8月～2011年2月入住本院的106例不能手术或不同意手术的中晚期中上段食管癌患者,将其随机分为治疗组和对照组,对照组采用常规放射治疗,全疗程约40d,治疗组在对照组的基础上给予奈达铂或氟尿嘧啶化疗,比较两组的近期疗效及不良反应情况.结果 治疗组和对照组的总有效率分别为86.79％、56.60％,差异有统计学意义（P＜0.05）；治疗组放射性食管炎、骨髓抑制、血液毒性反应、恶心呕吐等毒副反应的发生率均低于对照组,差异有统计学意义（P＜0.05）.结论 同步放化疗能提高中晚期中上段食管癌的有效率及短期生存率,明显减轻患者的不良反应及降低远处转移率,值得临床进一步推广应用,长期疗效有待进一步观察.

Clinical observation on concurrent radiotherapy and chemotherapy for advanced esophageal carcinoma

Objective To observe the short-term efficacy and adverse reactions of concurrent radiotherapy and chemotherapy for advanced esophageal carcinoma.Methods A total of 106 cases of patients with advanced esophageal carcinoma were randomly assigned to either treatment group or control group,with 53 patients in each.Both groups received the same concurrent radiotherapy and chemotherapy.Conventional radiation therapy was used to the control group,and the whole course was about 40 days.Nedaplatin or fluorouracil chemotherapy treatment was given to the treatment group on the basis of control group.The short-term efficacy and adverse reactions was compared between two groups.Results The short-term efficacy of the treatment group was 86.79%,compared with 56.60% of the control group, the difference was significant （P〈0.05）.Meanwhile,the incidence of toxicity and white blood cell toxicity in the treatment group was significantly lower than that of the control group,the difference was significant （P〈0.05）.Conclusion Concur- rent radiotherapy and chemotherapy can improve the short-term clinical efficacy in advanced esophageal carcinoma,and can significantly reduce the toxicity of radiotherapy and chemotherapy.Further follow-up data are need for long-term survival.