地佐辛联合氟比洛芬酯预防腹腔镜全麻苏醒期躁动的临床研究

目的探讨术毕前应用地佐辛联合氟比洛芬酯预防腹部腔镜患者全麻苏醒期躁动的效果。方法选取择期行腹部腔镜手术(包括外科中上腹腔镜手术及妇科盆腔腔镜手术)患者90例,年龄35~45岁,ASAⅠ~Ⅱ级,无明显重要脏器功能障碍。将患者随机平均分为4组,分别在术毕前10 min静脉给药。Ⅰ组给予地佐辛5 mg;Ⅱ组给予地佐辛10 mg;Ⅲ组给予氟比洛芬酯50 mg;Ⅳ组给予地佐辛5 mg,氟比洛芬酯50 mg。动态观察4组患者全麻苏醒期的躁动,血压波动,疼痛,呕吐以及术毕至拔管时间等指标变化。4组患者均术后1 h连接PCIA设备。结果Ⅰ组与Ⅲ组患者各项指标变化差异无统计学意义(P>0.05);Ⅱ组与Ⅳ组患者比较,拔管时间较长,恶心情况较多,差异均有统计学意义(P<0.05);Ⅳ组分别与其他3组比较,各项指标均明显高出,差异均有统计学意义(P<0.05)。结论术毕前应用地佐辛联合氟比洛芬酯可有效预防腹部腔镜手术患者全麻苏醒期的躁动等一系列不良反应。

Research on preventing laparoscopic patients' anesthetic on restlessness in the awaking stage of general anesthesia by using dezocine and flurbiprofen axetil before completing the operation

Objective: To study the effects on preventing laparoscopic patients′ anesthetic on restlessness in the awaking stage of general anesthesia by using dezocine and flurbiprofen axetil before completing the operation.Methods Laparoscopic surgery(including upper laparoscopic surgery and gynecologic pelvic cavity mirrors surgical procedure) was administered.Ninety patients(Aged between 35 and 45;ASA Ⅰ-Ⅱ) didn′t have obvious important viscera dysfunction.Patients were randomly divided into four groups and were given intravenous injection respectively ten minutes before the operation.Patients in groupⅠreceived 5 mg dezocine,groupⅡ 10 mg,group Ⅲ 50 mg and patients in group Ⅳ received 5 mg dezocine and dezocine flurbiprofen axetil 50 mg.Then dynamic observation of four groups was conducted in terms of general anesthesia to stir,fluctuations in blood pressure,pain,vomiting and the time from completing surgery to pulling out the tube.Four groups were connected to PCIA one hour after surgery.Results Differences in all indexes between patients in groupⅠand group Ⅲ had no statistical significance(P>0.05).Compared with those in group Ⅳ,patients in groupⅡ had delayed extubation time and more disgusted situations,which had statistical significance(P<0.05).Compared with the former three groups,all the indexes of groupⅣ were higher,this difference having statistical significance(P<0.05).Conclusion Using dezocine combined flurbiprofen axetil before operation can effectively prevent abdominal cavity mirrors surgical patients during anesthesia in the period of agitation and a series of adverse reactions.