| 血卟啉光敏剂加不同波段的光辐照对人癌细胞系杀伤作用的实验研究 |
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| 引用本文： | 董荣春,吕发度,顾鸿椿,陈暨耀,诸长生,蔡怀新,许德余.血卟啉光敏剂加不同波段的光辐照对人癌细胞系杀伤作用的实验研究[J].第二军医大学学报,1984(3). |
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| 作者姓名： | 董荣春 吕发度 顾鸿椿 陈暨耀 诸长生 蔡怀新 许德余 |
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| 作者单位： | 第二军医大学病理解剖学研究室
(董荣春，吕发度)，复旦大学物理系
(顾鸿椿，陈暨耀，诸长生，蔡怀新)，第二军医大学抗疟药研究室(许德余) |
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| 摘 要： | 本文应用国产的血卟啉光敏剂(PSD-007)加不同波段的光辐照,比较了不同波段的光敏反应对癌细胞的杀伤怍用。实验结果说明,光敏药物进入细胞后,经红光、绿光和紫光等不同波段的光辐照后,均能产生光敏反应而将癌细胞杀死。不同波段的光辐照对癌细胞杀伤效应的定量研究的结果为紫光的杀伤作用>绿光>红光。作者指出:由于紫光对组织的穿透性太差,所以在实际治疗中,红光仍为治疗表浅肿瘤的最佳波段。
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| 关 键 词： | 血卟啉光敏剂 细胞毒性 光波段 人癌细胞系 |
EXPERIMENTAL STUDIES ON THE CYTOTOXICITY OF HAEMATOPORPHYRIN DERIVATIVE AND LIGHT IN DIFFERENT WAVE-BANDS ON HUMAN TUMOR CELL LINE |
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| Dong Rongchun. et al.EXPERIMENTAL STUDIES ON THE CYTOTOXICITY OF HAEMATOPORPHYRIN DERIVATIVE AND LIGHT IN DIFFERENT WAVE-BANDS ON HUMAN TUMOR CELL LINE[J].Academic Journal of Second Military Medical University,1984(3). |
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| Authors: | Dong Rongchun |
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| Institution: | Dong Rongchun. et al |
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| Abstract: | Department of Pathological Anatomy of Second Military Medical College Photosensitive reaction of HPD and its cytotoxic action were studied, focussing on the spectral effect of the irradiating light. A human hepatocarcinoma cell line(SMMC-7721)with HPD was used. Killing effects on tumor cells after irradiation of light in three different wave-bands were observed, both qualitatively and quantitatively.Results were compared with those of Kinsey and Matsushima. |
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| Keywords: | hematoporphyrins cytotoxins light wave-band human tumor cell line |
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