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Enhancement of base hexose-monophosphate shunt activity of human polymorphonuclear leucocytes by human beta-interferon |
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| Authors: | A Ferrante V O Rencis |
| Affiliation: | 1. Division of Microbiology and Clinical Immunology, Institute of Pediatrics, Medical Academy, 30-063 Cracow, Poland;2. Institute of Medical Biochemistry, N. Copernicus Academy of Medicine, 31-034 Cracow, Poland |
| Abstract: | The effect of human fibroblast interferon (HuIFN-beta) on the HMP shunt activity of human polymorphonuclear leucocytes (PMNLs) was examined. HuIFN-beta caused an increase in the base level of the HMP shunt activity. No significant increase was observed in the same PMNLs stimulated with opsonized zymosan. The augmentation of this property, generally associated with antimicrobial and cytotoxic properties of the PMNLs, may be of potential importance in host defences against microbial and malignant diseases. |
| Keywords: | (Fab-Fc) recombinant immunoglobulins recombinant IgG with single Fab′ recombinant IgG with two Fab′ binding to Fc receptors PBM peripheral blood mononuclear cells FcR Fc receptor sIg surface immunoglobulin MEM Eagle's minimum essential medium AC adherent cells SRBC sheep red blood cells HRBC human red blood cells EA erythrocyte-antibody complexes ADCC antibody dependent cellular cytotoxicity PBS phosphate buffered saline |
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