Folic Acid Supplementation in Early Pregnancy,Homocysteine Concentration,and Risk of Gestational Diabetes Mellitus |
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| Affiliation: | 1. Better Outcomes Registry & Network Ontario, Ottawa, ON;2. Children''s Hospital of Eastern Ontario Research Institute, Ottawa, ON;3. Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON;4. School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON;5. Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON;6. Department of Obstetrics and Gynecology, Queen''s Perinatal Research Unit, Kingston General Hospital, Queen''s University, Kingston, ON;7. Department of Medicine, Division of Hematology, University of Ottawa, Ottawa, ON;8. Division of Endocrinology and Metabolism, University of Toronto, Toronto, ON;9. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON;1. Centre de Recherche en Infectiologie de l''Universite Laval, CHU de Québec-Université Laval, CHUL Hospital, Québec City, QC;2. Department of Obstetrics and Gynaecology, Faculty of Medicine, Université Laval, Québec City, QC;3. Department of Obstetrics and Gynaecology, CHU de Québec–Université Laval, CHUL Hospital, Québec City, QC;4. Cemag Care, Paris, France;1. Max Rady College of Medicine, University of Manitoba, Winnipeg, MB;2. Department of Obstetrics, Gynaecology & Reproductive Sciences, University of Manitoba, Winnipeg, MB;3. Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB;4. Department of Medicine, University of Calgary, Calgary, AB;5. Department of Obstetrics and Gynaecology, University of Calgary, Calgary, AB;1. Department of Obstetrics and Gynecology, Schulich School of Medicine and Dentistry, London, ON;2. Ottawa Hospital Research Institute, Ottawa, ON;3. Minimally Invasive Gynecology, The Fertility Clinic, London Health Science Center–Victoria Hospital, London, ON;4. The Fertility Clinic, London Health Science Center–Victoria Hospital, London, ON;5. Department of Family Medicine, University of Ottawa, Ottawa, ON;6. Department of Obstetrics & Gynecology, University of Toronto, Toronto, ON;7. Département de Chirurgie, Division de Chirurgie plastique, Université de Montréal, Montréal, QC;8. Department of Medicine, Division of Internal Medicine, University of Ottawa, Ottawa, ON;9. Division of Obstetrics & Gynecology, University of Ottawa, Ottawa, ON;10. Department of Obstetrics, Gynecology and Newborn Care, University of Ottawa, Ottawa, ON;11. Minimally Invasive Gynecology, The Ottawa Hospital, Ottawa, ON;1. Department of Epidemiology, Biostatistics & Occupational Health, Faculty of Medicine, McGill University, Montréal, QC;2. Department of Community Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB;3. Departments of Obstetrics & Gynaecology and Community Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB;1. Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;2. Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;3. Excellence Center in Diabetes, Hormone, and Metabolism, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand;1. Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON;2. Department of Anesthesiology and Pain Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON;3. Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON;4. Department of Physiology, Mount Sinai Hospital, University of Toronto, Toronto, ON;5. Lunenfeld-Tanenbaum Research Institute, Toronto, ON |
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| Abstract: | We used a prospective cohort of pregnant women at 12 to 20 weeks gestation between 2002 and 2008 in Ottawa and Kingston to evaluate the impact of early pregnancy folic acid supplementation on the risk of gestational diabetes mellitus. Among 7552 eligible women, 84 (1.11%) were diagnosed of gestational diabetes mellitus. Non-significant associations were observed between gestational diabetes mellitus and folate supplementation, homocysteine levels, and methylenetetrahydrofolate reductase 677 TT genotype. Although we found no significant associations between folic acid supplementation and the risk of gestational diabetes mellitus, genetic associations were not confounded by lifestyle or socioeconomic factors, which may have biased previous studies. |
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