Fas/FasL 在肺癌中的表达与淋巴结转移的关系

 目的　探讨 Fas/Fas L在肺癌中的表达及其与淋巴结转移的关系。方法　用免疫组化方法同时检测 42例非小细胞肺癌组织及肺癌转移淋巴结的 Fas/Fas L表达。结果　肺癌的 Fas表达率为 52 .3% (2 2 /4 2 ) ,其中鳞癌为 58.3% (1 4/2 4 ) ,腺癌为 44.4% (8/1 8) ,二者无显著差异 (P>0 .0 5)。肺癌的 Fas表达与有否淋巴结转移无明显相关 (P>0 .0 5)。肺癌的 Fas L表达为 57.1 % (2 4 /4 2 ) ,其中鳞癌 58.3% (1 4/2 4 )与腺癌 55.5% (1 0 /1 8)之间无显著差别 (P>0 .0 5)。肺癌伴淋巴结转移的 Fas L表达为 72 .7% (1 6/2 2 ) ,无淋巴结转移的 Fas L表达为 40 % (8/2 0 ) ,有显著差别 (P<0 .0 5)。1 6例 Fas L阳性肺癌的转移淋巴结均呈表达 Fas L。结论　肺癌表达 Fas L,并可能在肺癌转移机制中起免疫逃避作用。

The Association between Fas/FasL Expression in Lung Cancer and Lymph Node Metastasis

Objective To explore the association between Fas/FasL expression in lung cancer and lymph node metastasis .Methods Fas and FasL expressions were studied in 42 sections of lung cancer by immunohistochemistry.FasL was also detected in 16 sections of metastatic lymph node.Results Fas expression was detected in 52.3% of lung cancer with no difference between squamous cell carcinoma(58.3%) and adenocarcinoma(44.4%) (P>0.05) . There was no association between the loss of Fas expression in lung cancer and lymph node metastases. FasL was expressed in 57.1% of lung cancer with no difference between squamous cell carcinoma(58.3%) and adenocarcinoma (55.5%) (P>0.05) .There was a significantly higher incidence of FasL expression in lung cancers with lymph node metastasis compared with those without lymph node netastasis.All the metastatic lymph nodes from FasL-expressing lung cancer showed FasL expression.Conclusion Lung cancer expressed FasL and FasL may play an important role in the immune evasion in the metastasis of lung cancer.