宫瘤清胶囊联合米非司酮对子宫肌瘤的疗效

目的探讨宫瘤清胶囊联合米非司酮对子宫肌瘤的治疗效果,观察治疗前后激素水平的变化及不良反应。方法选择2012年1-12月来我院就诊的126例子宫肌瘤患者,随机分为观察组和对照组各63例,对照组患者给予米非司酮治疗,观察组患者在对照组的基础上加服宫瘤清胶囊,观察两组患者治疗前后子宫和肌瘤体积、激素水平变化及不良反应。结果观察组总有效率(92.06%)显著高于对照组(77.78%),两组比较差异有统计学意义(P<0.05);两组患者经治疗后子宫体积和最大肌瘤体积均明显缩小(P<0.05),且观察组缩小程度较对照组明显(P<0.05);经治疗后两组患者雌二醇(E2)、孕激素(P)、促卵泡素(FSH)、促黄体素(LH)含量均明显下降(P<0.05),且观察组激素水平下降程度较对照组明显(P<0.05);两组患者服药后均出现潮热、出汗、失眠等症状,但观察组较对照组轻微,停药后症状消失。结论宫瘤清胶囊联合米非司酮治疗子宫肌瘤能够提高临床疗效,比单纯用药更快地恢复激素水平,不良反应轻微。

Effect of Gongliuning capsule combined with mifepristone in the treatment of hysteromyoma

Objective To discuss the efficacy of Gongliuning capsule combined with mifepristone in the treatment of hysteromyoma,and observe the changes of hormone level and adverse reactions before and after treatment.Methods 126 patients with hysteromyoma treated in our hospital from January to December in 2012 were randomly divided into observation group（n = 63） and control group（n = 63）. Control group was treated with mifepristone,observation group was given Gongliuning capsule based on the treatment of control group. Volume of uterine and myoma,changes of hormone level before and after treatment,adverse reactions of the two groups were observed. Results The total effective rate of observation group（92. 06%） was significantly higher than that of the control group（77. 78%）,there was significant difference between the two groups（P ＆lt; 0. 05）. After the treatment,uterine volume and maximum myoma volume of the two groups had reduced significantly（P ＆lt; 0. 05）,and the reducing degree of observation group was more significant than that of the control group（ P ＆lt; 0. 05）;content of estradiol（ E2）,progesterone（P）,follicle stimulating hormone（FSH）,luteinizing hormone（LH） of the two groups had reduced significantly（ P ＆lt; 0. 05）,and the reducing degree of observation group was more significant than that of the control group（ P ＆lt; 0. 05）. After taking medicine,symptoms such as hot flashes,sweating,insomnia and so on appeared in two groups,but the observation group was more mild than control group,and symptoms disappeared after withdrawal. Conclusion Gongliuning capsule combined with mifepristone can improve the clinical efficacy in the treatment of hysteromyoma,which can make hormone level recovery more quickly than single medication,with mild adverse reactions.