| 硝酸益康唑克霉唑乳膏的制备及质量控制 |
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| 引用本文： | 高松田,徐兴亚,周泉. 硝酸益康唑克霉唑乳膏的制备及质量控制[J]. 辽宁药物与临床, 2014, 0(1): 74-76 |
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| 作者姓名： | 高松田 徐兴亚 周泉 |
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| 作者单位： | [1]江苏省兴化市皮肤病性病防治所,江苏兴化225700 [2]江苏省扬州市疾病预防控制中心皮肤病性病防治所,江苏扬州225009 [3]江苏省扬州市第一人民医院,江苏扬州225006 |
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| 摘 要： | 目的 研制硝酸益康唑克霉唑乳膏,并对其进行质量控制.方法 以硝酸益康唑、克霉唑为主药制备乳膏,采用HPLC法进行含量测定.结果 所制制剂为白色均匀细腻乳膏.克霉唑的含量为标示量的90%~110%,硝酸益康唑的含量为标示量的90%~110%,平均回收率分别为99.87%、101.11%,RSD分别为1.4%、1.8%.结论 该乳膏制备工艺简单,性质稳定,质量可控.
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| 关 键 词： | 硝酸益康唑 克霉唑 乳膏 制备 质量控制 |
Preparation and quality control of econazole nitrate and clotrimazole cream |
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| GAO Song-tian,XU Xing-ya,ZHOU Quan. Preparation and quality control of econazole nitrate and clotrimazole cream[J]. Liaoning Pharmacy and Clinical Remedies, 2014, 0(1): 74-76 |
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| Authors: | GAO Song-tian XU Xing-ya ZHOU Quan |
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| Affiliation: | 1. Xinghua Prevention and Cure Institute of Dermato-Venereolgy, Xinghua 225700, China; 2. Yangzhou Prevention and Cure Institute of Dermato-Venereolgy, Yangzhou 225009, China; 3. The NO. 1 Hospital of Yangzhou, Yangzhou 225006, China) |
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| Abstract: | Objective To prepare and control the quality of the cream content of econazole nitrate and clotrim- azole. Methods The cream was prepared by econazole nitrate and clotrimazole, the contents of econazole nitrate and ciotrimazole were determined by HPLC. Results The preparation was white cream, the average content of econazole nitrate was 90% - 110%. The average of clotrimazole was 90% N 110% with average recoveries 99. 87% , 101. 11% , RSD 1.4% , 1.8%. Conclusion This cream is simple and stable in preparing process, the quality can be controlled. |
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| Keywords: | Econazole nitrate Clotrimazole Cream Preparation Quality control |
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