肝纤维化的发病机理研究进展

慢性肝炎是我国的常见病 ,威胁着很多人的健康 ,大多数患者会发展成肝纤维化或肝硬化。肝纤维化是多种慢性肝病共有的病理改变 ,特征之一是细胞外基质产生与降解的失衡而导致的肝纤维的过度沉积。细胞外基质主要由肝星状细胞产生 ,同时多种细胞因子如TGF β1、PDGF、TNF α等也参与了这一过程。肝纤维化是可以逆转的 ,尤其在早期阶段。

Research Advance in Pathogenesis of Hepatic Fibrosis

Chronic hepatitis is very common in our country that threatens the health of many people. Most of the patients can develop into hepatic fibrosis or hepatic cirrhosis. Hepatic fibrosis is very common in many kinds of chronic liver disease.Excess production of fibre in liver is one of their characters,which results from the imbalance of production and assimilation of liver extracellular matrix.Extracellulaur matrix is mainly produced by hepatic stellate cell.At the same time,many kinds of cytokines,such as TGF-β_1,PDGF,TNF-α etc. are concerned with its course.The reversion of fibrosis can be carried out,particularly in the early course of the disease.