Inhibitory effects of saturated and polyunsaturated fatty acids on the cytochrome P450 3A activity in rat liver microsomes |
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| Authors: | Hirunpanich Vilasinee Sethabouppha Benjabhorn Sato Hitoshi |
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| Institution: | Faculty of Pharmacy, Mahasarakham University, Kantharavichai, Mahasarakham 44150, Thailand. |
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| Abstract: | This study was conducted to investigate the inhibitory effects of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) on cytochrome P450 3A (CYP3A). The inhibition of 6beta-hydroxy testosterone formation from testosterone in rat liver microsomes was used as an index of CYP3A activity. In the present study, among the three types of fatty acids, the rank order of inhibitory effects of fatty acids was SFAs
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