儿茶酚-邻-甲基转移酶基因多态性与强迫症

目的：探索儿茶酚-邻-甲基转移酶(COMT)基因多态性同强迫症临床特征的关系。方法：采用聚合酶链反应扩增技术与限制性片段长度多态(PCR-RFLP)测定120例强迫症(OCD)患者和130例健康对照者的基因型；根据Yale-Brown强迫量表评分将强迫症划分亚型。结果：强迫症患者COMT基因型与等位基因分布与健康对照者之间无显著差异；强迫行为组与强迫思想组的COMT基因型分布存在差异；G／A基因型多见于强迫行为组。结论：COMT基因多态可能对强迫症的发病没有直接的作用，但G／A基因型可能对症状是否表现为强迫动作有一定的影响。

A study of polymorphism of catechol-O-methyltransferase gene and obsessive-compulsive disorder

Objective:To explore the relation between polymorphism of catechol-O-methyltransferase (COMT) gene and clinical characters of obsessive-compulsive disorder (OCD). Method:120 OCD patients and 130 health controls were included in this study.All subjects were genotyped by the polymerase chain reaction and restriction fragment length polymorphism techniques.Yale-Brown obsessive compulsive scale (Y-BOCS) was used to determine the subtype of OCD. Results:There were no significant differences in genotype or allele frequencies of COMT gene between patients and controls.While significant difference was found in COMT genotype between obsessive subtype and compulsive subtype,and compulsive subtype had more G/A genotype. Conclusion:It is suggested that the polymorphism of COMT gene not play a major role in the genetic predisposition to OCD.The G/A genotype might determine whether the patient would have compulsive behavior.